RAF Typhoon FGR4s have operated alongside French aircraft in a joint strike against an hidden munitions depot in Syria used by the IS group, per a report from the UK's MoD.
The site, identified by surveillance, was believed to be containing munitions and bombs, the statement said, and was located in mountainous terrain just north of the historic site of Palmyra in Syria's central region.
"Our aircraft utilized precision-guided Paveway IV munitions to strike a series of entry passages leading to the site... early reports indicate the target was engaged successfully," officials stated.
There was no sign of any harm to civilians in the strike conducted Saturday night and each participating jet made a safe return, the defence officials confirmed.
The Typhoon FGR4s were backed up by a Voyager aerial refuelling aircraft.
IS - alternatively referred to as ISIS - established extremist governance over parts of both Syria and Iraq before its territorial defeat in 2019.
"This strike demonstrates our UK leadership, and resolve to stand shoulder to shoulder with our partners, to stamp out any resurgence of IS and their dangerous and violent ideologies in the Middle East," UK Defence Secretary the Defence Secretary remarked.
UK warplanes have performed overwatch operations over Syrian airspace to "prevent any attempted resurgence" of Islamic State following its routing at the climactic battle in Baghuz in 2019, the authorities noted.
"I must thank the personnel of the UK armed forces involved in this operation for their skill and their valour," he commented. "They were part of thousands of British troops deployed over the festive period. This mission, to take out dangerous terrorists who pose a risk to our security, shows how UK forces are ready to step up, all year round, ensuring Britain's security domestically and powerful internationally."
During December, the US military executed what it termed a "massive strike" targeting Daesh sites in Syria, after an attack resulted in the deaths of two US servicemembers and a civilian interpreter in Palmyra.
The United Nations says Daesh still has roughly 5-7 thousand fighters in Iraq and Syria.